Science Immunology

Supplementary Materials

Supplementary Material for:

Constitutive resistance to viral infection in human CD141+ dendritic cells

Aymeric Silvin, Chun I. Yu, Xavier Lahaye, Francesco Imperatore, Jean-Baptiste Brault, Sylvain Cardinaud, Christian Becker, Wing-Hong Kwan, Cécile Conrad, Mathieu Maurin, Christel Goudot, Santy Marques-Ladeira, Yuanyuan Wang, Virginia Pascual, Esperanza Anguiano, Randy A. Albrecht, Matteo Iannacone, Adolfo García-Sastre, Bruno Goud, Marc Dalod, Arnaud Moris, Miriam Merad, A. Karolina Palucka,* Nicolas Manel*

*Corresponding authors. Email: karolina.palucka{at}jax.org (A.K.P.); nicolas.manel{at}curie.fr (N.M.)

Published 7 July 2017, Sci. Immunol. 2, eaai8071 (2017)
DOI: 10.1126/sciimmunol.aai8071

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Preferential infection of CD1c+ DCs by HIV-1, HIV-2, and influenza virus, related to Fig. 1.
  • Fig. S2. Resistance of CD141+ DCs to HIV and influenza virus infection at the level of viral fusion, related to Fig. 2.
  • Fig. S3. RAB15 mediates resistance to HIV and influenza virus entry, related to Fig. 3.
  • Fig. S4. Infection of CD1c+ DCs selectively is required for cytosolic sensing of HIV and influenza virus, related to Fig. 4.
  • Fig. S5. Infection of CD1c+ selectively results in nonredundant antigen presentation of HIV and nonstructural influenza virus antigen, related to Fig. 5.
  • Fig. S6. DC subset cooperation for activation of antiviral T cells, related to Fig. 6.
  • Fig. S7. Resistance of CD141+ DCs to influenza virus in humanized mice, related to Fig. 7.
  • Table S1. List of antibodies used in the study.
  • Table S2. List of plasmids used in the study.
  • Table S3. List of primers to generate HIV-2(JK).
  • Table S4. List of primers used for gene expression analysis.

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Other Supplementary Material for this manuscript includes the following:

  • Table S5 (Microsoft Excel format). Raw data used to generate all graphs that have n < 25.

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