Science Immunology

Supplementary Materials

Supplementary Material for:

Tumor-derived exosomes modulate PD-L1 expression in monocytes

Franziska Haderk, Ralph Schulz, Murat Iskar, Laura Llaó Cid, Thomas Worst, Karolin V. Willmund, Angela Schulz, Uwe Warnken, Jana Seiler, Axel Benner, Michelle Nessling, Thorsten Zenz, Maria Göbel, Jan Dürig, Sven Diederichs, Jérôme Paggetti, Etienne Moussay, Stephan Stilgenbauer, Marc Zapatka, Peter Lichter, Martina Seiffert*

*Corresponding authors. Email: m.seiffert{at}

Published 28 July 2017, Sci. Immunol. 2, eaah5509 (2017)
DOI: 10.1126/sciimmunol.aah5509

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Plasma exosome quantification and correlation with clinical parameters.
  • Fig. S2. Northern blot analysis of hY4 in non-CLL exosomes and cells.
  • Fig. S3. Exosome uptake and triggered response in myeloid cells.
  • Fig. S4. hY4-induced gene expression changes and functional effects in monocytes.
  • Fig. S5. Relevance of TLR signaling in exosomal RNA–induced response.
  • References (50?54)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Patient information.
  • Table S2 (Microsoft Excel format). Proteome of CLL and healthy donor plasma– derived exosomes.
  • Table S3 (Microsoft Excel format). Small RNA sequencing data of CLL-derived exosomes and cells.
  • Table S4 (Microsoft Excel format). Quality control data of small RNA sequencing libraries.
  • Table S5 (Microsoft Excel format). Abundance of RNA species.
  • Table S6 (Microsoft Excel format). Gene expression results of monocytes upon hY4 treatment.
  • Table S7 (Microsoft Excel format). Comparison of serum cytokine levels with hY4-induced genes.
  • Table S8 (Microsoft Excel format). Raw data.

Files in this Data Supplement: