Science Immunology

Supplementary Materials

Supplementary Material for:

Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function

Valter R. Fonseca, Ana Agua-Doce, Ana Raquel Maceiras, Wim Pierson, Filipa Ribeiro, Vasco C. Romão, Ana Rita Pires, Susana Lopes da Silva, João Eurico Fonseca, Ana E. Sousa, Michelle A. Linterman, Luis Graca*

*Corresponding author. Email: lgraca{at}

Published 11 August 2017, Sci. Immunol. 2, eaan1487 (2017)
DOI: 10.1126/sciimmunol.aan1487

This PDF file includes:

  • Table S1. Clinical characteristics of 25 patients with primary (pSS) and secondary (sSS) Sjögren syndrome.
  • Fig. S1. Gating strategy for Tfh cells, CXCR5 Treg cells, and Tfr cells in human blood.
  • Fig. S2. Variation of blood Tfh cells and total Treg cells according to age.
  • Fig. S3. Sorting strategy for human blood naïve B cells, Tfh cells, CXCR5 Treg cells, and Tfr cells.
  • Fig. S4. Representative plots of CXCR5 Treg and Tfr cell suppression curves for coculture assay.
  • Fig. S5. Expression of CD45RO, CD45RA, and CD31 by human blood Tfh and Tfr cells.

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