Science Immunology

Supplementary Materials

Supplementary Material for:

Type III interferon is a critical regulator of innate antifungal immunity

Vanessa Espinosa, Orchi Dutta, Constance McElrath, Peicheng Du, Yun-Juan Chang, Bryan Cicciarelli, Amy Pitler, Ian Whitehead, Joshua J. Obar, Joan E. Durbin, Sergei V. Kotenko, Amariliz Rivera*

*Corresponding author. Email: riveraam{at}njms.rutgers.edu

Published 6 October 2017, Sci. Immunol. 2, eaan5357 (2017)
DOI: 10.1126/sciimmunol.aan5357

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Lymphoid-deficient and IFN-γ–deficient mice control fungal infection normally.
  • Fig. S2. Global transcriptional response of antifungal neutrophils.
  • Fig. S3. Inflammatory responses in IFNR−/− mice 48 hours after infection.
  • Fig. S4. Analysis of p47Phox−/− mice susceptibility to Aƒ infection.
  • Fig. S5. Validation of hIFNLR1 antibody.
  • Fig. S6. Neutrophil-specific gene excision is efficiently targeted in MRP8Cre mice.
  • Fig. S7. Type III IFN transcription in CCR2-depleted mice is rescued by adoptive transfer of CCR2+ monocytes.
  • Table S1. Exact P values of asterisks shown in the figures.

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