Science Immunology

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Supplementary Material for:

Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin

Akash H. Verma, Jonathan P. Richardson, Chunsheng Zhou, Bianca M. Coleman, David L. Moyes, Jemima Ho, Anna R. Huppler, Kritika Ramani, Mandy J. McGeachy, Ilgiz A. Mufazalov, Ari Waisman, Lawrence P. Kane, Partha S. Biswas, Bernhard Hube, Julian R. Naglik,* Sarah L. Gaffen*

*Corresponding author. Email: sarah.gaffen{at} (S.L.G.); julian.naglik{at} (J.R.N.)

Published 3 November 2017, Sci. Immunol. 2, eaam8834 (2017)
DOI: 10.1126/sciimmunol.aam8834

This PDF file includes:

  • Fig. S1. TCRαβ+ cell proliferation in knockout mice and gating strategies.
  • Fig. S2. Expansion of innate TCRαβ+ cells during OPC.
  • Fig. S3. Baseline frequency of innate TCRαβ+ cells is similar in WT and Ccr6−/− mice.
  • Fig. S4. Virulence factors and TCRαβ+ cell expansion.
  • Fig. S5. Factors that activate TCRαβ+ cell expansion.
  • Fig. S6. Candidalysin signals synergistically with IL-17 and TNFα but not with IL-22.
  • Fig. S7. Model of first encounter to C. albicans in the oral epithelium.

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