Science Immunology

Supplementary Materials

Supplementary Material for:

Sustained T follicular helper cell response is essential for control of chronic viral infection

Ute Greczmiel, Nike Julia Kräutler, Alessandro Pedrioli, Ilka Bartsch, Paola Agnellini, Gregor Bedenikovic, James Harker, Kirsten Richter, Annette Oxenius*

*Corresponding author. Email: oxenius{at}

Published 1 December 2017, Sci. Immunol. 2, eaam8686 (2017)
DOI: 10.1126/sciimmunol.aam8686

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Basic characterization of the CD4-DTR mouse line.
  • Fig. S2. Sustained activity of CXCR5 or Bcl6-expressing TFH cells is required for the development of LCMV-neutralizing antibodies and control of protracted infection.
  • Fig. S3. Immunofluorescence stainings in splenic thin sections.
  • Fig. S4. Viral escape is not driven by pressure of CTLs.
  • Fig. S5. CD8 T cell responses are unaffected by the absence of TFH or LCMV-specific CD4 T cells.

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