Science Immunology

Supplementary Materials

Supplementary Material for:

Migratory CD11b+ conventional dendritic cells induce T follicular helper cell?dependent antibody responses

Jayendra Kumar Krishnaswamy, Uthaman Gowthaman, Biyan Zhang, Johan Mattsson, Louis Szeponik, Dong Liu, Renee Wu, Theresa White, Samuele Calabro, Lan Xu, Magalie A. Collet, Marina Yurieva, Samuel Alsén, Per Fogelstrand, Anne Walter, William R. Heath, Scott N. Mueller, Ulf Yrlid, Adam Williams,* Stephanie C. Eisenbarth*

*Corresponding author. Email: stephanie.eisenbarth{at}yale.edu (S.C.E.); adam.williams{at}jax.org (A.W.)

Published 1 December 2017, Sci. Immunol. 2, eaam9169 (2017)
DOI: 10.1126/sciimmunol.aam9169

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Skin migratory cDC2s transport most of the antigen to draining LNs after subcutaneous immunization.
  • Fig. S2. Intranasal immunization targets antigen to both migratory cDC subsets.
  • Fig. S3. Dock8 deficiency is not associated with impaired lung or MedLN DC development or survival.
  • Fig. S4. Generation and characterization of DC-Dock8Δ mice.
  • Fig. S5. cDC2 characteristics suggest a unique localization within MedLNs.
  • Fig. S6. Definition of T cell zone and T-B border in MedLN.

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