Science Immunology

Supplementary Materials

Supplementary Material for:

Dysregulated invertebrate tropomyosin–dectin-1 interaction confers susceptibility to allergic diseases

Naina Gour, Stephane Lajoie,* Ursula Smole, Marquitta White, Donglei Hu, Pag? Goddard, Scott Huntsman, Celeste Eng, Angel Mak, Sam Oh, Jung-Hyun Kim, Annu Sharma, Sophie Plante, Ikhlass Haj Salem, Yvonne Resch, Xiao Xiao, Nu Yao, Anju Singh, Susanne Vrtala, Jamila Chakir, Esteban G. Burchard, Andrew P. Lane, Marsha Wills-Karp*

*Corresponding author. Email: mwkarp{at} (M.W.-K.); slajoie1{at} (S.L.)

Published 23 February 2018, Sci. Immunol. 3, eaam9841 (2018)
DOI: 10.1126/sciimmunol.aam9841

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Flow-gating scheme for lung ILC2.
  • Fig. S2. ST2 blockade in Clec7a−/− mice reduces HDM-induced airway mucus.
  • Fig. S3. Dectin-1 on lung structural cells protects against manifestations of allergic asthma.
  • Fig. S4. Dectin-1 expression on APCs and epithelial cells from human nasal tissue.
  • Fig. S5. Control Fc protein does not bind to invertebrate tropomyosin.
  • Fig. S6. Invertebrate tropomyosin abrogates chitin-induced airway inflammation.
  • Fig. S7. Allelic variation in rs58677678 in 1000 Genomes populations.
  • Table S1. Location, frequency, and effect size of rs58677678.
  • Table S2. Association between CLEC7A SNP (rs58677678) and expression of CLEC7A gene in multiple tissues.
  • Table S3. Patient information for CRS.
  • Table S4. Patient information for asthmatics.

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