Science Immunology

Supplementary Materials

Supplementary Material for:

Suppression of diabetes by accumulation of non–islet-specific CD8+ effector T cells in pancreatic islets

Gustaf Christoffersson, Grzegorz Chodaczek, Sowbarnika S. Ratliff, Ken Coppieters, Matthias G. von Herrath*

*Corresponding author. Email: matthias{at}lji.org

Published 23 March 2018, Sci. Immunol. 3, eaam6533 (2018)
DOI: 10.1126/sciimmunol.aam6533

This PDF file includes:

  • Methods
  • Fig. S1. Ag-driven mouse models of T1D.
  • Fig. S2. CTL activation and expansion is a requirement for pancreatic recruitment.
  • Fig. S3. Immune suppression by non–Ag-specific CD8+ T cells was not due to a ?transfer bias.?
  • Fig. S4. No signs of differences in the cytokine environment in the pancreas.
  • Reference (48)

Download PDF

Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). Activated CTLs infiltrate islets irrespective of the presence of their cognate Ag.
  • Movie S2 (.avi format). No islet infiltration in the absence of cognate Ag and islet inflammation.
  • Movie S3 (.avi format). Differential behavior of islet-specific CTLs and non–islet-specific CTLs at islets.
  • Movie S4 (.avi format). High amounts of CTLs not recognizing local Ag reduces the number of interactions with APCs.
  • Movie S5 (.avi format). High amounts of CTLs not recognizing local Ag reduces the number of interactions with APCs.

Files in this Data Supplement: