Science Immunology

Supplementary Materials

The PDF file includes:

  • Fig. S1. T-CTLs are expanded in tuberculoid leprosy as compared with lepromatous leprosy.
  • Fig. S2. T-CTLs express the IL-15 receptor, and IL-15 causes an increased expression of GZMB and causes selective proliferation of T-CTLs over M-CTLs.
  • Fig. S3. T-CTLs are CD8+ TEMRA cells.
  • Fig. S4. Generation and examination of CTL profiles.
  • Fig. S5. Analysis of the specific T-CTL signature reveals an enrichment of NK surface modulatory receptors.
  • Fig. S6. NK receptor expression on CTL subsets correlates with the number of cytotoxic molecules expressed.
  • Fig. S7. Comparison of NK receptors between cytotoxic cell populations between two donors.
  • Fig. S8. T-CTLs express unique αβ TCRs.
  • Fig. S9. NCAM1, KLRC1, and KLRC2 are the most differentially expressed NK receptors between T-CTL and D-CTL subsets across two donors.
  • Fig. S10. CD56, NKG2C, and NKG2A are enriched in the T-CTL subset.
  • Fig. S11. NKG2C and NKG2A mark CD8+ T-CTLs.
  • Fig. S12. Across healthy donors, NKG2C marks T-CTLs.
  • Fig. S13. Generation and confirmation of a CD3+CD8+ D-CTL and T-CTL clone.
  • Fig. S14. Antimicrobial activity is increased by αCD3 coating.
  • Fig. S15. Antimicrobial activity correlated with CTL subset composition.
  • Fig. S16. NKG2C marks T-CTLs within T-lep donors.
  • Legend for table S1

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Raw data used to generate figures.

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