Science Immunology

Supplementary Materials

The PDF file includes:

  • Fig. S1. ISG levels in DCs and MΦ after L.m. infection.
  • Fig. S2. The role of IFNAR on MΦ during L.m. infection.
  • Fig. S3. Usp18 expression after L.m. infection.
  • Fig. S4. ISG levels in WT and Usp18−/− after L.m. infection.
  • Fig. S5. The role of USP18 in DCs after low dose (400 CFU) of L.m.
  • Fig. S6. DC numbers in Usp18fl/fl CD11c-Cre mice after L.m. infection.
  • Fig. S7. Bacterial titers in sorted macrophages and DCs after L.m. infection.
  • Fig. S8. The role of USP18 in the uptake and early replication of L.m.
  • Fig. S9. The role of USP18 in inhibiting TNF-α signaling.
  • Fig. S10. USP18 inhibits ROS production.
  • Fig. S11. USP18 inhibits antibacterial effect of TNF-α but not IFN-γ.
  • Fig. S12. ISG levels in sorted DCs after LCMV infection.
  • Table S1. Mutation sites of murine and human USP18 and the consequences on the functional domains.

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