Science Immunology

Supplementary Materials

The PDF file includes:

  • Ethics statement
  • Case reports
  • Supplementary Materials and Methods
  • Fig. S1. Clinical and genetic features of kindreds with AR IL-12Rβ2 or IL-23R deficiency.
  • Fig. S2. IL12RB2 Q138X and IL23R C115Y mutations abolish the response of the encoded receptor to its cognate cytokine ligand.
  • Fig. S3. Population genetics for IL12RB1, IL12RB2, and IL23R.
  • Fig. S4. Immunophenotype of IL-12Rβ2–, IL-12Rβ1–, and IL-23R–deficient patients.
  • Fig. S5. Flow cytometry gating.
  • Fig. S6. Nonantigen-specific cytokine production, and antigen-specific proliferation, precursor frequency, and cytokine production by memory CD4+ T cells from healthy controls and IL-12Rβ2–, IL-23R–, and IL-12Rβ1–deficient patients.
  • Fig. S7. Cytokine receptor expression and responses of MAIT cells and NKT cells to stimulation with IL-12 or IL-23.
  • Table S1. Estimated proportions of deleterious and nondeleterious amino acid variants in IL12RB1, IL12RB2, and IL23R.
  • Table S2. Relative levels of IFN-γ production in response to IL-12 versus IL-23 in different cell subsets.
  • Legend for table S3
  • References (5669)

Download PDF

Other Supplementary Material for this manuscript includes the following:

  • Table S3 (Microsoft Excel format). Raw data used to generate dot plots, heat maps, and bar graphs.

Files in this Data Supplement: