Science Immunology

Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Case Reports
  • Fig. S1. Population and medical genetics.
  • Fig. S2. Response to IFN-α/β, IL-10, IL-12, and IL-23 in TYK2-deficient cell lines transduced with different TYK2 alleles.
  • Fig. S3. Response to IFN-α/β in cell lines with different TYK2 genotypes.
  • Fig. S4. Response to IL-12 and IL-10 in cell lines with different TYK2 genotypes.
  • Fig. S5. Response to IL-23 in cell lines with different TYK2 genotypes.
  • Fig. S6. Induction of target genes after IL-10, IFN-α, and IL-23 stimulation in cell lines with different TYK2 genotypes.
  • Fig. S7. Auto- and transphosphorylation of P1104A TYK2 and P1057A JAK2.
  • Fig. S8. Analysis of leukocytes with different TYK2 genotypes.
  • Table S1. Summary of the TYK2 genotypes among the different cohorts of patients and healthy individuals.
  • References (9496)

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Other Supplementary Material for this manuscript includes the following:

  • Table S2 (Microsoft Excel format). Raw data used to generate dot plots and bar graphs.

Files in this Data Supplement: