Science Immunology

Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Skip lesions in older Tac-fostered Nod2−/–Cybb−/− mice.
  • Fig. S2. Kinetics of intestinal inflammation in doubly deficient Nod2/Cybb mice.
  • Fig. S3. Cellular infiltrates in the large intestine of Tac- and Jax-fostered mice.
  • Fig. S4. CD-like inflammation in Nod2−/–Cybb−/− mice is characterized by TH1 immune responses.
  • Fig. S5. Characterization of Tac-fostered doubly deficient Nod2/Cybb mice before the development of colitis.
  • Fig. S6. Analysis of the gut microbiota in Tac- and Jax-fostered doubly deficient Nod2/Cybb mice and quantification of mucus-dwelling bacteria in fostered mice.
  • Fig. S7. Increased abundance of Mucispirillum in inflamed colonic areas in Nod2−/–Cybb−/− mice.
  • Fig. S8. ROS production after microbial stimulation.
  • Fig. S9. Immunoglobulin production in fostered mice.
  • Fig. S10. Mucispirillum-specific colonization and Ig production in JH−/−, IgA−/− and FcRn−/− mice.
  • Fig. S11. Mucispirillum-specific IgA and IgG cooperate in conferring protection against colitis in doubly deficient Nod2/Cybb mice.
  • Fig. S12. Specificity of Mucispirillum-induced intestinal inflammation in doubly deficient Nod2/Cybb mice.
  • Fig. S13. Efficiency of B cell depletion in doubly deficient Nod2/Cybb mice.
  • References (6973)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). The abundances and LEfSe data of individual OTUs in Jax- and Tac-fostered mice.
  • File S1 (Microsoft Excel format). Data in tabular format.

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