Science Immunology

Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. TET-mediated DNA hydroxymethylation correlates with demethylation and enhancer activity.
  • Fig. S2. Phenotypic features of WT and Tet2/3 DKO B cells.
  • Fig. S3. TET family proteins are important for B cell–intrinsic CSR.
  • Fig. S4. Decreased Aicda expression in Tet2/3 DKO B cells.
  • Fig. S5. TET-responsive element TetE1 regulates CSR and Aicda mRNA expression in the CH12 B cell line.
  • Fig. S6. TET proteins sustain enhancer accessibility.
  • Fig. S7. Analysis of TET-dependent accessible regions.
  • Fig. S8. AP-1 proteins in activated B cells.
  • References (59–73)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Differentially expressed genes between WT and Tet2/3 DKO B cells.
  • Table S2 (Microsoft Excel format). Time-series analysis of RNA expression in WT B cells.
  • Table S3 (Microsoft Excel format). Primer sequences.
  • Table S4 (Microsoft Excel format). Reagents and resources.
  • Table S5 (Microsoft Excel format). Raw data.

Files in this Data Supplement: