Science Immunology

Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Generation of Gab3-deficient mouse models.
  • Fig. S2. Loss of Gab3 does not affect peripheral NK cell numbers or their maturation.
  • Fig. S3. Loss of Gab3 does not affect NK cell development in the bone marrow.
  • Fig. S4. The R27C missense mutation disrupts the PH domain binding to phosphotyidylinositols.
  • Fig. S5. Altered gene expression in gd8.5 uNK cells (CD45+/CD3/CD122+) isolated from Gab3KO compared with WT uNK cells.
  • Fig. S6. Loss of Gab3 has limited effect on the decidual depth, labyrinth, or junctional zone area at gd12.5.
  • Fig. S7. Functional Gab3 is required for controlling trophoblast invasion.
  • Fig. S8. WT mice treated with anti-NK1.1 antibodies (PK136) have efficient depletion of NK cells in the spleen and placentas at gd12.5.
  • References (6467)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Raw data in Excel spreadsheet.

Files in this Data Supplement: