Science Immunology

Supplementary Materials

This PDF file includes:

  • Fig. S1. Gating strategy for sorting immune cells from the small intestine of C57BL/6 mice.
  • Fig. S2. Circadian regulation of ILC3s by light cues and microbiota-derived signals.
  • Fig. S3. Construct design and experimental validation of BAC transgenic IL-22–eGFP reporter mice.
  • Fig. S4. BMAL1ΔRorc mice have intact ILC2 and TH17 cell responses in the intestine and similar cellularity of ILC3s in lymphoid tissues.
  • Fig. S5. BMAL1 deficiency affects T-bet+ ILC3s in the large intestine.
  • Fig. S6. BMAL1 deficiency impairs intestinal ILC3s at weaning.
  • Fig. S7. Analysis of circadian genes in intestinal ILC3s from patients with IBD.
  • Fig. S8. A circadian clock is essential for homeostasis of ILC3s in the gut.
  • Table S1. Clinical metadata associated with the human samples.
  • Table S2. Primers used in the study.

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