Science Immunology

Supplementary Materials

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  • Fig. S1. Tissue-resident Vγ6+ γδ T cells are enriched in IL-17 producers in the perinatal period.
  • Fig. S2. γδ T cells are absent from the brain parenchyma.
  • Fig. S3. Absence of IL-17 or γδ T cells does not impair mice exploratory behavior or anxiety.
  • Fig. S4. Exploratory behavior in short-term Y-maze test is unaffected in IL-17−/−, TCRδ−/−, BMC, and WT mice after intracerebroventricular injection.
  • Fig. S5. Short-term memory is affected in IL-17−/−, TCRδ−/−, BMC, and WT mice after intracerebroventricular injection of anti–IL-17.
  • Fig. S6. IL-17−/− and TCRδ−/− females display short-term memory deficits but normal exploratory behavior in the Y-maze.
  • Fig. S7. Mice deficient in IL-17 or γδ T cells share the same gut microbiota as littermate controls.
  • Fig. S8. Long-term memory in the MWM is not affected by the absence of IL-17 or γδ T cells.
  • Fig. S9. Long-term memory in the Y-maze is not affected in the absence of IL-17 or γδ T cells.
  • Fig. S10. Short-term memory in the MWM is impaired in the absence of IL-17 or γδ T cells.
  • Fig. S11. Proteomics analyses reveal mild changes in distinct signaling pathways in the IL-17−/− hippocampus.
  • Fig. S12. Proteomics analyses reveal mild changes in discrete synaptic pathways in the IL-17−/− hippocampus.
  • Fig. S13. TCRδ−/− mice display impaired basal transmission after short-term Y-maze.
  • Fig. S14. Conditional depletion of IL-17RA in microglia, astrocytes, or both does not fully recapitulate Y-maze deficits observed in IL-17−/− mice.
  • Table S1. Proteomic dataset analysis.
  • Table S2. List of antibodies used for FACS analysis.
  • Legend for table S3

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Other Supplementary Material for this manuscript includes the following:

  • Table S3 (Microsoft Excel format). Raw data sets for main figures.

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