Science Immunology

Supplementary Materials

The PDF file includes:

  • Fig. S1. Evaluation of Card11 E134G mutant mice.
  • Fig. S2. NF-κB activation in E134G mutant and Card11 KO mice.
  • Fig. S3. BM chimeric mouse model by using GFP+ WT mice.
  • Fig. S4. BCR downstream signaling pathways, B cell apoptosis, and cell cycle analysis in Card11 E134G mice.
  • Fig. S5. AKT/FOXO1 signal axis in WT, heterozygous, and homozygous E134G mutant mice.
  • Fig. S6. CARD11 interacts with AKT and regulates AKT K63 ubiquitination.
  • Fig. S7. B cell development in Card11 K215M mutant mice.
  • Fig. S8. Phenotype analysis of WT, heterozygous, and homozygous K215M mutant mice.
  • Fig. S9. GCB response analysis in Card11 E134G and K215M mutant mice.
  • Fig. S10. Dynamic expression of Card11 during B cell development.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Raw data in Excel spreadsheet.

Files in this Data Supplement: