Science Immunology

Supplementary Materials

The PDF file includes:

  • Fig. S1. Effect of the Purnama mutation on IgE responses.
  • Fig. S2. Accelerated IgE responses in Prkd2-deficient mice after immunization with papain.
  • Fig. S3. Immune cells in Prkd2-deficient mice.
  • Fig. S4. Increased number of TFH and GC B cells in Prkd2−/− spleens.
  • Fig. S5. Increased number of TFH in Prkd2−/− lymph nodes.
  • Fig. S6. Prkd2−/− TH2 cells.
  • Fig. S7. TFH, GC B cells, and antibody responses in Prkd2−/− Bcl6fl/flCD4-Cre+ mice.
  • Fig. S8. IL-2 production and IL-2–regulated immune cells in Prkd2−/− mice.
  • Fig. S9. Bcl6 expression in Prkd2−/− B cells.
  • Fig. S10. Effect of B cell–intrinsic Prkd2 deficiency on GC B cell development.
  • Fig. S11. Flow cytometric gating strategy to sort PD-1highCXCR5high and PD-1lowCXCR5low CD4+ T cells.
  • Fig. S12. Frequencies of TFH or GC B cells and IgE response to immunization in Il12a−/− mice.
  • Fig. S13. Enlarged lymph nodes and spontaneous BALT formation in Prkd2−/− mice.
  • Fig. S14. Regulation of TFH-dependent antibody responses by mutual inhibition between Prkd2 and Bcl6.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Raw data file (Excel spreadsheet).

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