Science Immunology

Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. TAD clusters neighboring 3′RR.
  • Fig. S2. lnCSRIgA deletion in the mouse genome.
  • Fig. S3. Physiological consequences of deletion of lncCSRIgA.
  • Fig. S4. CSR and SHM in lncCSRIgA−/− cells.
  • Fig. S5. TADIgH and TADlncCSR interaction and locus A and lncCSRIgA interaction.
  • Fig. S6. IgA CSR frequency of locus A and locus B mutant B cell lines.
  • Fig. S7. lncCSRIgA interaction with CTCF-associated cofactors and working model of action in TADlncCSRIgA.
  • Fig. S8. Interactions among multiple genomic regions infer potential coregulatory relationships between TADs or sub-TADs with ncRNA expression.
  • Fig. S9. Gating strategy for FACS analysis.
  • Fig. S10. Complete image (Fig. 3D).
  • Fig. S11. Complete image (Fig. 6F).
  • Table S1. List of reagents and resources.
  • Table S2. List of primers used.
  • Table S3. Table of conserved genes placed between mouse and human TADIgH and TADlncCSR.
  • Table S4. Table of lncRNA-CSR interacting proteins identified from two independently performed purifications.
  • Legends for tables S5 and S6
  • References (5361)

Download PDF

Other Supplementary Material for this manuscript includes the following:

  • Table S5 (Microsoft Excel format). Table of interactions among multiple genomic regions infer potential coregulatory relationships.
  • Table S6 (Microsoft Excel format). Raw data.

Files in this Data Supplement: