Science Immunology

Supplementary Materials

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  • Fig. S1. Identification of DR1501-restricted GAD65 epitopes by TGEM.
  • Fig. S2. Tetramer staining of GAD65 and IGRP antigen–specific cells.
  • Fig. S3. GAD65137–156 is the dominant DR1501-restricted GAD65-specific T cell epitope.
  • Fig. S4. GAD65137–156 is a naturally processed epitope.
  • Fig. S5. Cytokine profiles of DR1501-restricted Treg and Teff clones.
  • Fig. S6. Total and Flu-specific CD4+CD127CD25+ Tregs among different haplotype groups.
  • Fig. S7. Suppression of DQ8-restricted GAD65 Teffs with DR1501-restricted Tregs in transwell chamber assay.
  • Fig. S8. Effects of anti–IL-10 or exogenous IL-2 in suppression assays.
  • Table S1. Specificities of DR0301-, DR0401-, DR1501-, and DQ6-restricted Teff clones.
  • Table S2. Specificities of DR1501-restricted Treg clones.

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