Science Immunology

Supplementary Materials

The PDF file includes:

  • Fig. S1. Schematic of VLR assembly in lampreys.
  • Fig. S2. Characterization of the LRRCT-encoded hypervariable loop regions of VLRB assemblies.
  • Fig. S3. Structure of VLRB repertoires in animals of different ages.
  • Fig. S4. CRISPR-Cas9–mediated mutagenesis of CDA2.
  • Fig. S5. Deduced protein sequences of mutant alleles in CDA2 crispants.
  • Fig. S6. Somatic mosaicism in CDA2 crispants.
  • Table S1. Amino acid length distribution of the LRRCT loop region in VLRB assemblies of individual larvae.
  • Table S3. List of primer sequences used for the indicated analyses.

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Other Supplementary Material for this manuscript includes the following:

  • Table S2. List of amino acid sequences of the LRRCT loop region in VLRB assemblies of individual larvae (in Excel spreadsheet).
  • Table S4. Raw data file (in Excel spreadsheet).

Files in this Data Supplement: