Science Immunology

Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. IRF5 deficiency and cecum physiology at steady state.
  • Fig. S2. IRF5 deficiency and cecum in inflammation.
  • Fig. S3. MBMC: Monocyte development in the bone marrow and blood.
  • Fig. S4. scRNA-seq: Monocyte development in blood.
  • Fig. S5. scRNA-seq: MNP populations in cLP at steady state.
  • Fig. S6. scRNA-seq: IRF5 effect on blood monocytes and cLP MNPs at steady state.
  • Fig. S7. scRNA-seq: MNP populations in inflamed colon.
  • Fig. S8. scRNA-seq and bulk RNA-seq: Comparison of IRF5-dependent genes.
  • Fig. S9. IRF5 in monocyte to macrophage differentiation.
  • Fig. S10. scRNA-seq: Monocyte and macrophage populations in inflamed colon.
  • Fig. S11. scRNA-seq: Gene expression in Cd11c versus Cd206 macrophages.
  • Table S1. List of antibodies used for surface staining.
  • Table S2. List of antibodies used for intracellular staining.

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Other Supplementary Material for this manuscript includes the following:

  • Table S3. Raw data in Excel spreadsheet.

Files in this Data Supplement: