Science Immunology

Supplementary Materials

The PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. Diagrams of sectioning planes through the mouse head.
  • Fig. S2. Parenchymal cells within the OB and brain survive VSV infection after intranasal inoculation.
  • Fig. S3. Virus-specific CTLs flux calcium for longer durations while undergoing stable interactions.
  • Fig. S4. Generation of floxed β2M transgenic mice.
  • Fig. S5. VSV does not infect microglia and CTB traffics from OSNs to OB glomeruli.
  • Fig. S6. Quantification of microglia and infiltrating cells in the OB using different microglia depletion methods.
  • Legends for movies S1 to S4
  • References (102, 103)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). Virus-specific CTLs rapidly migrate across VSV infected axon tracts within the infected outer nerve layer.
  • Movie S2 (.mp4 format). Virus-specific CTLs survey the infected glomerular layer with the OB.
  • Movie S3 (.mp4 format). Antiviral CTLs engage cognate antigen and flux calcium within the infected OB.
  • Movie S4 (.mp4 format). Antiviral CTLs flux calcium upon contact with microglia.

Files in this Data Supplement: