Science Immunology

Supplementary Materials

The PDF file includes:

  • Fig. S1. Western blot data.
  • Fig. S2. Detailed characteristics of human mAbs.
  • Fig. S3. Indirect ELISA data for all mAbs.
  • Fig. S4. Representative densities from the EV-D68: Fab EV68-228 electron density map.
  • Fig. S5. Estimates of immune complex map resolutions.
  • Fig. S6. Comparison of the Fab binding sites.
  • Fig. S7. Road maps showing an enlarged view of the Fab footprints.
  • Fig. S8. Bulky side chains of the EV68-228 Fab heavy chain.
  • Table S1. Characteristics of participants who provided PBMCs.
  • Table S2. Sequence characteristics of human mAbs.
  • Table S3. Cryo-EM data acquisition parameters and refinement statistics.
  • Table S4. Structural contact amino acid residues of EV-D68 and respective Fabs.
  • Table S5. Neurologic scores of individual mice treated with antibody after EV-D68 inoculation.
  • Table S6. Neutralization escape amino acid mutations.
  • Table S7. EV-D68 isolates used.

Download PDF

Other Supplementary Material for this manuscript includes the following:

  • Table S8 (Microsoft Excel format). Raw data file (Excel spreadsheet).

Files in this Data Supplement: