Science Immunology

Supplementary Materials

The PDF file includes:

  • Fig. S1. Representative gating strategy of relevant lymphocyte populations.
  • Fig. S2. Fc.WT shows a comparable activity with mouse recombinant IL-2.
  • Fig. S3. Fc.mutein activity in Treg cells ranges from full potency to complete functional abrogation.
  • Fig. S4. Fc.muteins retain their ability to bind CD25.
  • Fig. S5. Fc.muteins retain Treg cell selectivity across a wide dose range on activated T cells.
  • Fig. S6. Fc.Mut24 remains Treg cell selective across a wide dose range in vivo.
  • Fig. S7. Fc.Mut24 expands Treg cells more specifically and effectively than daily low-dose IL-2 and IL-2ic in vivo.
  • Fig. S8. Sustained Treg cell enrichment after Fc.Mut24 treatment.
  • Fig. S9. Reduced Treg cell selectivity of Fc.Mut24 in pancreatic cells.
  • Table S1. Panel of Fc.IL-2 muteins.

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Other Supplementary Material for this manuscript includes the following:

  • Table S2 (Microsoft Excel format). List of key reagents.
  • Table S3 (Microsoft Excel format). Raw data file.

Files in this Data Supplement: