Science Immunology

Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Overview of experimental design, quality control metrics of single-cell sequencing data, and assessment of overall antigen receptor diversity in healthy individuals and patients with UC.
  • Fig. S2. scRNA-seq reveals heterogeneous B lymphocyte clusters.
  • Fig. S3. Analyses of clonal relationships in health and UC.
  • Fig. S4. scRNA-seq reveals heterogeneous T lymphocyte clusters.
  • Fig. S5. Analysis of Zeb2 knockdown or Zeb2-deficient Treg cells.
  • Fig. S6. Mass cytometry analysis of peripheral blood.
  • Fig. S7. CD8+ T cell analysis and histopathology in mouse models of intestinal inflammation.
  • References (6775)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Raw data file.
  • Table S2 (Microsoft Word format). Demographics for patient samples.
  • Table S3 (Microsoft Excel format). Quality control metrics for single-cell sequencing data.
  • Table S4 (Microsoft Excel format). Differential gene expression analyses of plasma cell clusters.
  • Table S5 (Microsoft Excel format). Differential gene expression analyses between γδ T cell clusters T8, T13, and T16.
  • Table S6 (Microsoft Excel format). Differential gene expression analyses between T7 cluster cells from patients with UC versus healthy individuals.
  • Table S7 (Microsoft Excel format). Metal-conjugated antibodies for mass cytometry.
  • Table S8 (Microsoft Excel format). Differential gene expression analyses of CD8+ tissue-resident memory cell clusters.
  • Table S9 (Microsoft Excel format). Putative Eomes gene targets in intestinal CD8+ T cells.

Files in this Data Supplement: