Science Immunology

This PDF file includes:

  • Methods
  • Fig. S1. Characterization of R-TEn and R1B/R2B.
  • Fig. S2. R-TEn and R1B/R2B are essential for cell type–specific Rag1/Rag2 expression.
  • Fig. S3. R1B and R2B regulates compartmentalization, local compaction, sub-TAD, and loop formation.
  • Fig. S4. E protein binding to enhancer and promoter regions are indispensable for Rag gene expression.
  • Fig. S5. E-box mutations in R-TEn-p1 did not affect other gene loci.
  • Fig. S6. Development of Rag SEs during T and B cell differentiation, in comparison with BMDM.
  • Fig. S7. Comparative analysis of R-TEn, R1B, and R2B enhancers among vertebrates.
  • Table S1. GSE numbers for figures.
  • Table S2. Tag density at enhancer regions.

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