Science Immunology

The PDF file includes:

  • Fig. S1. Number of PCR positive cases with a sample taken during each week since symptom onset.
  • Fig. S2. Smooth average measurements of IgG, IgM, and IgA against SARS-CoV-2 spike protein receptor binding domain among PCR positive cases across time.
  • Fig. S3. Individual trajectories for 16 randomly selected individuals with 4 or more measurements.
  • Fig. S4. Measurements of IgG, IgM, and IgA against SARS-CoV-2 spike protein receptor binding domain among pre-pandemic controls and symptomatic PCR positive cases.
  • Fig. S5. Receiver operating characteristic curve from random forest models and isotype contributions.
  • Fig. S6. Confusion matrices and out-of-bag error estimates for random forest models.
  • Fig. S7. Confusion matrices and out-of-bag error estimates for random forest models with downsampled controls.
  • Fig. S8. Measurements of IgG, IgA, and IgM against the RBD of other coronaviruses among pre-pandemic controls and PCR positive cases.
  • Fig. S9. Correlation between plasma and dried blood spot measurements (DBS).
  • Table S1. Full amino acid sequences of the coronavirus receptor-binding domains (RBDs) used in this study.
  • Table S2. Predictive accuracy of multiple isotypes for classifying controls and cases over time since symptom onset.
  • Table S3. Parametric estimates of median time to seroconversion for each isotype by different patient characteristics.

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Other Supplementary Material for this manuscript includes the following:

  • Table S4. Raw data file (Excel spreadsheet).