Science Immunology

The PDF file includes:

  • Fig. S1. MACS sorting of human CD206+ BAL AM.
  • Fig. S2. Gating strategies of murine flow cytometry.
  • Fig. S3. Lung function and immune cell profile after bleomycin in Acod1−/− mice.
  • Fig. S4. Fibrotic phenotype in Acod1−/− mice at d7 and d21 after bleomycin.
  • Fig. S5. Baseline lung function and immune cell recruitment in WT and Acod1−/− mice.
  • Fig. S6. Itaconate controls Tr-AM metabolism.
  • Fig. S7. AMs in the adult human lung after transplant express ACOD1.
  • Fig. S8. Profibrotic genes are increased in Mo-AM compared with Tr-AM after bleomycin.
  • Fig. S9. BAL cell composition and collagen gene expression post-adoptive transfer.
  • Fig. S10. Exogenous itaconate limits HLF wound healing.
  • Fig. S11. Exogenous itaconate is antifibrotic.
  • Table S1. Individual demographics of samples used for qPCR analysis (Fig. 1A).
  • Table S2. Individual demographics of samples used for GC-MS analysis (Fig. 1B).

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Other Supplementary Material for this manuscript includes the following: