Science Immunology

The PDF file includes:

  • Fig. S1. Gut microbial structure in MS and healthy controls (HC).
  • Fig. S2. CSF IgA and CNS-infiltrating IgA+ B cells are enriched in active MS but absent in noninflammatory disease and healthy controls.
  • Fig. S3. IgA-producing cells traffic across the BBB in active MS.
  • Fig. S4. Assessment of gut mucosal homing markers and antimicrobial reactivity of CNS IgA-producing cells.
  • Fig. S5. Assessment of reactivity against human brain tissue.
  • Fig. S6. Epitope mapping mAb-1.
  • Fig. S7. Commensal-specific IgA antibody-secreting cells (ASC) detected in human blood of patients with MS.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Clinical characteristics of patients and controls in the study (Excel spreadsheet).
  • Table S2. IgA-SEQ data analysis (Excel spreadsheet).
  • Table S3. Cluster, read count, and mutation analysis for B cell repertoire data (Excel spreadsheet).
  • Table S4. List of glycan array epitopes (Excel spreadsheet).
  • Table S5. Raw data spreadsheet (Excel spreadsheet).