Science Immunology

The PDF file includes:

• Fig. S1. Validation of MEP1 with OT-II Tg and wild-type C57BL/6 CD4⁺ T cells.
• Fig. S2. MEP1 plus mTOR inhibition limits antigen-specific CD4⁺ naïve T cell activation and proliferation, but promotes T_reg cell development in vitro.
• Fig. S3. Rapamycin has no effect on polyclonal host CD4⁺ T_M and T_reg development.
• Fig. S4. Strategy of human ARTE assay and metabolic inhibitor effect on microbiota flagellin–specific CD4⁺ T cell cytokine production upon restimulation.

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Other Supplementary Material for this manuscript includes the following:

• Table S1 (Microsoft Excel format). List of DEGs in the remaining donor-derived CBir1 TCR Tg CD4⁺ cells after metabolic ablation.
• Table S2 (Microsoft Excel format). Raw data table.