Science Immunology

The PDF file includes:

• Fig. S1. Inflammatory T cells at site of infection confound a tissue-residency signature.
• Fig. S2. Controlling for T helper function improves tissue-residency signature.
• Fig. S3. Protein expression confirms T_H1 and T_FH phenotypes in the lung.
• Fig. S4. Progressive differentiation of resident CD4⁺ T cell subsets.
• Fig. S5. T_RH cell generation requires B cells and T cell–intrinsic Bcl6.
• Fig. S6. CD4⁺ T_RH cells localize in lung B cell clusters.
• Fig. S7. Maintenance of T_RH cells requires antigen presentation.
• Fig. S8. T_RH cells are plastic and promote local antibody production during rechallenge.
• Reference (71)

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Other Supplementary Material for this manuscript includes the following:

• Table S1 (Microsoft Excel format). Raw data file.
• Table S2 (Microsoft Excel format). List of antibodies used for flow cytometry and histology.
• Table S3 (Microsoft Excel format). Cluster-defining genes.