Science Immunology

The PDF file includes:

  • Additional Materials and Methods
  • Fig. S1. “Late” CD4+ T cell help shapes respiratory mucosal memory CD8+ T and B cell immunity.
  • Fig. S2. Parenchymal tissue CD4+ T cells deliver local help to CD8+ T and B cells.
  • Fig. S3. scRNA-seq identifies a population of lung TH cells that exhibit TFH features.
  • Fig. S4. Total RNA-seq identifies PD-1HiFR4Hi cells that exhibit features of both TFH and TRM.
  • Fig. S5. Bhlhe40 deficiency impairs tissue CD4+ T cell responses.
  • Fig. S6. T cell–specific BCL6 deficiency leads to impaired lung CD8+ memory and B cell immunity.
  • Fig. S7. Bhlhe40 is required for lung memory CD8+ T and B cell responses.
  • Fig. S8. TRH cells help local development of memory CD8+ T and B cells.
  • Fig. S9. CD40L signal is likely involved in TRH cell help to tissue B cells.
  • Fig. S10. TRH cells help CD8+ TRM cells through IL-21–dependent mechanisms.
  • Fig. S11. Epitope-specific IL-21 signaling in CD8+ T cells.
  • Fig. S12. Graphical summary.
  • References (65, 66)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Raw data and statistics for Figs. 1 to 7.