Science Immunology

The PDF file includes:

  • Fig. S1. CD8+ T cell responses in COVID-19 illness.
  • Fig. S2. Virus-reactive CD8+ T cells show transcriptomic heterogeneity.
  • Fig. S3. Analysis of CD8+ memory T cells expressing activation markers ex vivo from COVID-19 patients.
  • Fig. S4. Exhausted SARS-CoV-2-reactive CD8+ cells are increased in mild COVID-19 illness.
  • Fig. S5. Pro-survival features in SARS-CoV-2-reactive CD8+ T cells from patients with severe COVID-19.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Human subject details (Excel spreadsheet).
  • Table S2. Summary of all FACS data (Excel spreadsheet).
  • Table S3. Single-cell sequencing quality controls and subject-specific cell numbers (Excel spreadsheet).
  • Table S4. Single-cell cluster enriched transcripts (Excel spreadsheet).
  • Table S5. Gene lists utilized for Gene Set Enrichment Analysis and Signature Module Scores (Excel spreadsheet).
  • Table S6. Subject-specific TCR clonotype data (Excel spreadsheet).
  • Table S7. Cluster-specific TCR clonotype data (Excel spreadsheet).
  • Table S8. Single-cell differential gene expression analysis (Excel spreadsheet).
  • Table S9. Ingenuity Pathway Analysis (Excel spreadsheet).
  • Table S10. Summary statistics for exhaustion-related genes across clusters (Excel spreadsheet).
  • Table S11. Raw data file (Excel spreadsheet).