Science Immunology

The PDF file includes:

  • Fig. S1. Transcriptome analysis of human ILC2s from the circulation and a mucosal tissue microenvironment.
  • Fig. S2. In vitro differentiation of resting CD45RA+ ILC2s into inflammatory CD45RO+ ILC2s.
  • Fig. S3. ILC2 conversion into a CD45RO+ inflammatory phenotype is associated with BATF and IRF4 transcription factor activity.
  • Fig. S4. Circulating CD45RO+ ILC2 frequencies are increased in uncontrolled and steroid-resistant asthma.
  • Fig. S5. CD45RO+ inflammatory ILC2s are resistant to suppression by corticosteroids.
  • Fig. S6. Phenotypic conversion of CD45RA+ ILC2s by dexamethasone and mechanisms underlying steroid resistance of CD45RO+ ILC2s.
  • Legends for supplementary tables
  • Table S3. Asthma patient cohort characteristics.
  • Table S4. Antibodies used in this study.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Differentially expressed genes between PB and NP ILC2s (Excel spreadsheet).
  • Table S2. Gene expression values for genes belonging to six transcription factor families across PB, NP, and PB + type 2 ILC2s (Excel spreadsheet).
  • Table S5. Raw data file (Excel spreadsheet).