Science Immunology

The PDF file includes:

  • Fig. S1. Treatment and sampling course for pediatric cohort over hospital stay.
  • Fig. S2. Innate immune compartment in MIS-C is broadly comparable to Pediatric COVID-19.
  • Fig. S3. T cell proliferation in MIS-C is greater than in COVID-19.
  • Fig. S4. NK and CD8+ MAIT cell activation in MIS-C is greater than in COVID-19.
  • Fig. S5. Vascular patrolling CX3CR1+ populations in MIS-C are uniquely proliferative in MIS-C.
  • Fig. S6. A transition towards B cell memory subsets from naive is associated with IFN╬│ in both MIS-C and pediatric COVID-19.
  • Fig. S7. Total and activated cTfh frequencies are not associated with PB responses in either pediatric cohort.
  • Fig. S8. T cell activation in MIS-C is elevated compared to severe pediatric COVID-19 disease.
  • Fig. S9. Features of CD4+ T cell activation start to normalize over time, coincident with treatment and recovery from disease.
  • Table S1. Patient characteristics.
  • Table S2. Panel for peripheral blood mononuclear cell flow cytometric staining.
  • Table S3. Lineage panel for whole blood flow cytometric staining.
  • Table S4. Flow cytometry features included in UMAP analysis.
  • Table S5. Sample n per figure panel.

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Other Supplementary Material for this manuscript includes the following:

  • Table S6. Raw Data File (excel spreadsheet)