Science Immunology

The PDF file includes:

  • Materials and Methods
  • Fig. S1. β8 expression by tumor cells drives tumor growth, which is blocked by C6D4 Fab in vivo.
  • Fig. S2. Tumor Treg isolation and expression of select Treg genes by RNAseq in this report compared with single-cell RNAseq from splenic Treg.
  • Fig. S3. Non-Treg CD4+ T cells express cell surface L–TGF-β, are converted to Treg by contact with β8-LLC cells, and are the source of suppressive iTreg generated on αvβ8.
  • Fig. S4. Murine nTregs do not express detectable levels of cell-surface αvβ8.
  • Fig. S5. LRRC32 (GARP) is most highly expressed by Treg and stromal cells and NRROS by myeloid cells.
  • References (6773)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Raw data table (Excel spreadsheet).