Science Immunology

The PDF file includes:

  • Materials and Methods
  • Fig. S1. THL potently inhibits NLRP3 inflammasome activation in murine and human macrophages.
  • Fig. S2. THL suppresses NLRP3-related inflammatory responses in vivo.
  • Fig. S3. Therapeutic role of THL in MCD-induced NAFLD.
  • Fig. S4. BRISC inactivation prevents the assembly of NLRP3 inflammasome.
  • Fig. S5. Inhibition of NLRP3 inflammasome by THL is independent of Rpn11, Csn5, or AMSH.
  • Fig. S6. THL does not directly affect the interaction between the core components of NLRP3 inflammasome in HEK-293T cells.
  • Fig. S7. HL inhibits NLRP3 inflammasome activation in vitro and in vivo.
  • Fig. S8. Pharmacokinetics of HL.
  • Fig. S9. Schematic diagram showing the potential mechanism of action of THL.
  • Table S1. Pharmacokinetic properties of HL.

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Other Supplementary Material for this manuscript includes the following:

  • Table S2. Raw data file (Excel spreadsheet).