Table 1 Validation of gene module activities that predict vaccination response in the discovery cohort for young adults.

Shaded modules were identified in the discovery cohorts and then independently validated (FDR ≤ 10% and P ≤ 0.01).

Gene moduleDiscovery cohortsValidation cohort
PFDRGene module
activity
PFDRGene module
activity
BCR signaling (M54)0.0100.2750.1210.0000.0020.173
Platelet activation
(III) (M42)
0.0020.2750.1420.0080.0420.140
Inflammatory
response (M33)
0.0060.2750.1900.0220.0800.193
Transmembrane
transport (II)
(M191)
0.0100.275−0.0560.0820.227−0.038
TBA (M198)0.0090.2750.1770.1470.3230.101
TBA (M72.1)0.0080.275−0.1270.2190.4010.073
TBA (M72.0)0.0060.275−0.1370.4340.6680.054
E2F1 targets (Q4)
(M10.1)
0.0030.275−0.0720.4860.6680.035
Enriched in T cells (II)
(M223)
0.0020.275−0.1620.5770.684−0.057
Enriched in activated
dendritic cells/
monocytes (M64)
0.0090.2750.2500.6220.6840.066
E2F1 targets (Q3)
(M10.0)
0.0070.275−0.0510.9080.9080.005