Table 1 A comparison between mouse and human TRM.

Ab, antibody; SG, salivary gland.

MiceHumans
Techniques to define tissue residencyParabiosis (7, 12, 3941), in vivo labeling
(7, 8, 11, 46), Ab depletion (10, 47, 48), FTY720
(11, 4952), transplantation (46, 53), and
transcriptional profiling (1315, 32, 83).
Transcriptional profiling (18, 22, 23, 32, 33, 71, 93),
Ab depletion (54), and transplantation (5557).
Canonical phenotypeCD69+CD103+/−CD69+CD103+/−
Accessory markersCD101, CD49a, PD-1, CXCR6, CLA, LFA1, CD11a,
CXCR3, and CCR10 (7, 14, 53, 69, 78, 89).
CD101, CD49a, PD-1, CXCR6, CLA, and CCR8
(18, 27, 32, 33, 74, 93, 94).
TFsHobit and Blimp1 (13), Runx3 for CD8+ TRM (83),
and Notch for CD103+CD8+ TRM maintenance (32).
Hobit, Blimp1, and Runx3 (18, 33) and Notch/RBPj
enriched on lung TRM (32, 33, 57)
Tissue maintenanceMaintained over months: skin (12, 91), gut (6),
brain (64), lung (CD4+ TRM) (11, 48), liver (89), and
SG (108). Wane over months: lung CD8+ TRM (91).
Maintained over years: skin (56), intestine (55), and
lung (57). TRM frequency maintained over life
(17, 24).
Features in nonlymphoid tissuesSkin CD103+/−CD4+ TRM most frequent in naïve
mice (45); epidermal CD103+CD8+ TRM and dermal
CD103+/−CD4+ TRM accrue in infected mice (65).
Liver CD8+ TRM lack CD103 (89).
Epidermal CD103+CD4+ TRM and dermal
CD103CD4+ TRM most frequent in healthy skin
(66). Liver CD8+ TRM express CD103 (27).
Features in lymphoid tissuesLN CD8+ TRM infrequent (40), more abundant in
dirty mice (38). BM CD8+ T cells recirculate (39).
Large TRM pool (18, 22, 71) and LN-specific
transcriptional profile (22). BM CD69+CD4+ T cells
quiescent, broad specificities (26).
Role in immunityProtective in viral (5, 7, 43, 90), bacterial
(49, 67, 73, 104, 107), parasitic (89), and fungal (106)
infections.
Correlation of antigen-specific TRM abundance to
viral control (27, 71, 113).
Potential target for vaccinationDemonstrable (50, 52, 89, 98, 119124)Promising