Table 1 Properties of the TCRs of the mouse and human B:9-23–specific CD4T cells.
V α domain*V β domain
T cellVα (TRAV)*CDR1CDR2CDR3Jα*Vβ (TRBV)*CDR1CDR2CDR3Jβ*
Mouse type A
I.2915 (10)DTASSYIRSNVDAASPSNSGGSNYKLT532 (1)NSQYPWLRSPGDTCSAGLGYEQY2-7
PCR1-1013.1 (5D-4)DSASNYIRSNMEAASKTGGNNKLT5611 (16)ISGHSAFRNQAPASSLDGGQGLEQY2-7
12-4.113.1 (5D-4)DSASNYIRSNMEAASGANSGGSNYKLT532 (1)NSQYPWLRSPGDTCSPGLGNEQY2-7
AS15010.8 (13-1)STTLNSRLFYNPAISSGSWQLI222 (1)NSQYPWLRSPGDTCSADQNSYNSPLY1-6
4F713.1 (5D-4)DSASNYIRSNMEAGTGNYKYV332 (1)NSQYPWLRSPGDTCSADQNQAPL1-5
Mouse type B
8F1013.1 (5D-4)DSASNYIRSNMEAASRRGSGGSNYKLT538.2 (13-2)TNNHNNSYGAGSASGGLGGDEQY2-7
8-1.113.1 (5D-4)DSASNYIRSNMEAASKTGGNNKLT5612 (15)VSGHNDFRSKSLASSLGWGDEQY2-7
12-4.413.1 (5D-4)DSASNYIRSNMEAASASGGSNTKLT5312 (15)VSGHNDFRSKSLASSPGQGTTLY1-3
AS9113.2 (5)DSASNYIRSNMESRGNNNRIF311 (5)HLGHNAYNLKQLASSQLGGLDTQY2-5
Human “type A”
T1D-33 (17)TSINNLIRSNERATDAGYNQGGKLI235.1 (5-1)ISGHRSYFSETQASSAGNTIY1-3
T1D-48 (13-1)DSASNYIRSNVGAASKASNTGKLI38.3 (12-3)ILGHNTYRNRAPASLKATDTQY2-3
T1D-102.2 (12-3)NSAFQYYTYSSGASSRGGGNTGELF267.1 (4-1)HMGHRASYEKLSASSRGGGNTGELF2-2

*The Vα, Jα, Vβ, and Jβ are named using the classic nomenclature with the newer The International Immunogenetics Information System (IMGT) nomenclature for Vα and Vβ in parentheses.

†CDR1 and CDR2 sequences are the six amino acids at the tips of these loops. Amino acids in boldface are predicted to interact similarly with peptide or MHC.

‡CDR3 sequences are amino acids between the conserved C at the end of the V element and the conserved F in the FGXG motif of the J element.