Table 1 Parameter estimates from the best-fitting model describing the linear flow from incoming monocytes to CD11bhigh cells, EpCAM+ cells, and mature donor LCs.

Data show the estimated value with 95% confidence interval.

ParameterEstimate95% CI
Mean time spent in EpCAM+0.10 days0.0084–0.30
Efficiency of maturation from EpCAM+ to donor LCs0.0420.0068–0.053
Mean residence time of donor LCs73 days14–1100
Mean interdivision time in donor LCs at week 15.8 days2.4–14
Mean interdivision time in donor LCs at week 26.8 days4.9–16
Mean interdivision time in donor LCs at week 318 days14–66
Mean interdivision time in donor LCs at week 454 days32–250
Mean interdivision time in donor LCs at week 1078 days44–370
Relative contribution of proliferation in donor LCs to
influx at week 1
1.40.84–11
Relative contribution of proliferation in donor LCs to
influx at week 2
0.220.15–0.86
Relative contribution of proliferation in donor LCs to
influx at week 3
0.240.16–0.74
Relative contribution of proliferation in donor LCs to
influx at week 4
0.310.18–1.06
Relative contribution of proliferation in donor LCs
to influx at week 10
137–44